Stocks fell sharply Tuesday after new signs that the global economy is weakening and reports of difficulties in U.S.-China trade talks. That decline broke a four-day winning streak for U.S. indexes.

Major global indexes fell after the International Monetary Fund trimmed its economic forecasts for 2019 and 2020, pointing to risks including trade tensions and rising interest rates. China’s government said its economy grew in 2018 at the slowest pace since 1990.

U.S. stocks took further losses after the Financial Times reported that the Trump administration canceled a proposed meeting with Chinese trade officials this week.

Technology and internet firms skidded. Energy companies sank with oil prices. Industrial firms fell, hurt by the slower growth forecast and trade concerns as well as some weak fourth-quarter earnings. Bond prices climbed as investors looked for safer investments.

The Standard & Poor’s 500 index slid 37.81 points, or 1.4%, to 2,632.90. The Dow Jones industrial average fell 301.87 points, or 1.2%, to 24,404.48. The Nasdaq composite sank 136.87 points, or 1.9%, to 7,020.36. The Russell 2000 index of smaller-company stocks declined 25.05 points, or 1.7%, to 1,457.45.

Lately, global markets have rallied as investors began to feel that a slowdown in the world economy might not be that painful. The S&P 500 is up 5% in 2019 and has jumped 12% since its recent low Dec. 24. But Tuesday’s losses were a reminder that investors remain sensitive to clues that the global economy is weakening, and the U.S.-China trade dispute may be the top threat to economic growth.

Technology and industrial companies took some of the biggest losses. Farm equipment maker Deere fell 3.5% to $158.84. Chipmakers dropped, with Nvidia falling 5.2% to $148.77.

Aluminum products maker Arconic slumped 16% to $17.09 after it said it is no longer considering a sale. Formerly a part of aluminum giant Alcoa, Arconic said it didn’t receive any offers it thought were in its best interests.

Power tools maker Stanley Black & Decker sank 15.5% to $115.69 after its forecast for 2019 fell short of Wall Street estimates.

Bond prices rose. The yield on the 10-year Treasury note fell to 2.74% from 2.78%.

Home builders sank after U.S. home sales cratered in December and price growth declined to the lowest level in more than six years.

U.S. crude slid 2.3% to $52.57 a barrel. Brent crude, used to price international oils, fell 2% to $61.50 a barrel. Natural gas dived 12.7% to $3.04 per 1,000 cubic feet. Wholesale gasoline fell 3.5% to $1.40 a gallon. Heating oil fell 0.8% to $1.90 a gallon.