With the coronavirus surge worsening, California officials have issued new recommendations on when infected people can end their isolation — guidance that is stricter than that issued earlier this week by the U.S. Centers for Disease Control and Prevention.

California says asymptomatic people with coronavirus infections can exit their isolation after the fifth day following a positive test, but only if they get a negative test result.

By contrast, the CDC guidelines don’t require a follow-up negative test; they recommend that those without symptoms can end their isolation after five days but should continue to wear a mask around others for five additional days.

Dr. Robert Wachter, chair of the UC San Francisco Department of Medicine, praised California’s stricter guidelines.

“Kudos,” Wachter wrote. “Safer than [the CDC’s] version.”

The move comes as a coronavirus surge is taking hold across the state.

Los Angeles County on Friday reported more than 27,000 new cases, fueled in part by the highly transmissible Omicron variant.

Overall, California’s reported average daily coronavirus caseload has more than quadrupled in the last two weeks — pushing infection levels significantly higher than they were during the summer surge linked to the Delta variant.

“The risk for virus transmission has never been higher in our county,” Los Angeles County Public Health Director Barbara Ferrer said

Thursday.

The Los Angeles County Department of Public Health endorsed California’s new isolation recommendations and will codify them in its latest local mandatory health order.

California’s new guidelines still largely mirror those of the CDC. Both have shortened the minimum time recommended for isolation from 10 days to five for asymptomatic people.

Both the CDC and California officials also suggest quarantine for people who are not up to date on their booster shots if they have been exposed to someone who has tested positive for the coronavirus.

Officials recommend calling 911 if anyone has difficulty breathing, chest pain or pressure on the chest; bluish lips or face; is confused or hard to wake; or has other emergency symptoms.

The Omicron variant is believed to be two to four times as contagious as the previously dominant Delta.

People who are eligible for booster shots but haven’t yet received them are at increased risk for infection.

“Data from South Africa and the United Kingdom demonstrate that vaccine effectiveness against infection for two doses of an mRNA vaccine is approximately 35%,” the CDC said in a statement. “A COVID-19 vaccine booster dose restores vaccine effectiveness against infection to 75%.”

Here’s a summary of California’s new guidelines on isolating after testing positive or being exposed to the coronavirus.

If you test positive for the coronavirus:

Stay home for at least five days after the onset of symptoms or after you were tested, regardless of vaccination status, even if you have no symptoms.

After the fifth day, you can exit isolation if a test shows that you are negative, and you have no symptoms or symptoms are resolving. (Officials recommend getting a rapid antigen test for this purpose, as PCR tests — which require saliva or nasal swabs that are sent to a lab for processing and take a day or two to get results — are so sensitive that they can show a positive test result for several months, long after you’ve stopped being contagious.)

These state guidelines will be requirements in Los Angeles County.

“You can’t be a ‘positive’ person and decide on Day 6, you’re leaving isolation in L.A. County. You can leave if you’ve had a negative test on Day 5, you’re asymptomatic or your symptoms have dramatically improved, and you’re fever-free,” Ferrer said.

If you can’t get a test or choose not to take one, you can exit isolation after the 10th day, as long as you have no symptoms or they are resolving.

If you have a fever, stay isolated until it resolves.

If symptoms other than fever are not resolving, continue to isolate until symptoms resolve or until after the 10th day.

Wear a well-fitting mask around other people for 10 days, especially indoors. Surgical masks or higher-grade masks — such as N95, KN95 and KF94 — are recommended.

Cooperate with contact tracing staffers from your local health department, who will notify people you’ve been around while you were infectious.

If you’ve been exposed but haven’t fallen ill or tested positive:

Recommendations on how to behave following an exposure to someone who has tested positive for the coronavirus vary depending on your vaccination status and whether you’ve received a booster shot.

A close contact or exposure is defined as someone who has spent at least 15 minutes over a 24-hour period within six feet of a person who has tested positive for the coronavirus.

If you’ve been exposed in this way, and you have been recently vaccinated or have received a booster shot:

Get tested on the fifth day after exposure.

Wear a well-fitting mask (N95, KN95 or KF94) around others for 10 days, especially indoors.

If you test positive, follow isolation recommendations.

If symptoms develop, test and stay home.

The guidance is different for those who have been exposed but are unvaccinated or have not received a booster shot:

Stay home for at least five days after your last contact with a person who has tested positive for the coronavirus.

Take a test on the fifth day.

Your quarantine can end after the fifth day if symptoms are not present and a test is negative.

If you’re unable to test or choose not to, and you have no symptoms, your quarantine can end on the 10th day.

Wear a well-fitting mask around others for 10 days, especially indoors.

If you test positive, follow the isolation recommendations.

If symptoms develop, test and stay home.

Vaccinated people are eligible for booster shots six months after their second dose of the Pfizer-BioNTech or Moderna shots and two months after the primary dose of the Johnson & Johnson shot.

What does it mean to stay home

during isolation?

Do not leave the house except to get medical care.

Get food and supplies delivered to you or have someone drop them off.

Don’t have visitors.

Wear a face covering around others, including family members and housemates.

Disinfect a shared bathroom after each use, or use a separate bathroom if possible.

Open windows if you must be in a shared space.

Stay at least six feet from other people, especially high-risk individuals such as those age 65 and older; those who are severely overweight or have a chronic disease such as cancer, diabetes or heart or lung disease; and those who have a weakened immune system.